Program

Conference Programme

Wednesday, March 24, 2010

13.00 – 17.00	Conference registration
17.00 – 17.15	Opening of the conference
17.30 – 18.30	Opening lecture: Chair: Gregor Serša Richard Heller - Gene Transfer using Electroporation: Translation to the Clinic.
9.00 – 20.30	Dinner
20.30 – 21.30	Round table: Meet the Editor Chair: Gregor Serša & Saša Markovič Damijan Miklavčič: Publishing scientific results in peer-reviewed journals: from the other side of the table

Thursday, March 25, 2010

9.00 – 10.30	Section 1: Carcinogenesis Chairs: Metka Filipič & Tom Hei
9.00 – 9.25	Tom Hei: The Ying and Yang of the ßigH3 gene in Human Cancer
9.25 – 9.50	Metka Filipič: Dietary factors in prevention of cancer and mechanisms of chemoprevention
9.50 – 10.15	Damjan Glavač: Pathogenetic and clinical relevance of microRNAs in colorectal cancer
10.15 – 10.30	Miroslav Machala: Advances in mechanistic in vitro studies on chemical-induced tumor promotion and progression
10.30 – 11.00	Break
11.00 – 13.00	Section 2: Mechanisms of Tumour Progression - I Chairs: Gunilla Høyer Hansen & Boris Turk
11.00 – 11.25	Muriel Golzio: Gene expression regulation by electro-delivery of RNAi inducing molecules
11.25 – 11.50	Gunilla Høyer Hansen: In vivo inhibition of effects dependent on pericellular proteolysis by anti-mouse uPA and uPAR monoclonal antibodies
11.50 – 12.15	Ciro Isidoro: Cross talk between autophagy and apoptosis: An opportunity for cancer chemotherapy
12.15 – 12.40	Boris Turk: Anti-cancer therapy: Potential of lysosome-mediated cell death:
12.40 – 12.55	Matic Legiša: Posttranslational modification of 6-phosphofructo-1-kinase as a key characteristic of cancer metabolism
13.00 – 15.00	Lunch
15.00 – 16.35	Section 2 – Mechanisms of tumour progression - II Chairs: Geoffry Pilkington & Simone P. Niclou
15.00 – 15.25	Geoffry Pilkington: GD3/GD3A and CD133 are critical modulators of therapeutic resistance and behaviour in malignant glioma
15.25 – 15.50	Simone P. Niclou: Bevacizumab changes blood flow and increases cell invasion in glioblastoma xenografts
15.50 – 16.05	Rachel Daniel: Development of the dorsal skin-fold window chamber in mice for the analysis of angiogenic growth factors
16.05 – 16.20	Špela Ferjančič : Metastasis results in sustained endothelial activation: potential for early detection
16.20 – 16.35	Miha Milek: S-adenosylmethionine stabilizes thiopurine S-methyltransferase and modulates redox capacity
16.35 – 17.00	Break
17.00 – 18.35	Section 3: Immunomodulation and immunotherapy Chairs: Roman Jerala & Pawel Kalinski
17.00 – 17.25	Pawel Kalinski: Dendritic Cells in Immunotherapy of Established Cancer: Role of Signal 3 and Signal 4
17.25 – 17.50	Roman Jerala: Insights into the molecular mechanism of TLR activation – opportunities for therapeutic intervention
17.50 – 18.05	Nataša Obermajer: Tumour-derived PGE2 promotes the SDF-1/CXCR4 guided recruitment of immature dendritic cells to tumours
18.05 – 18.20	Urban Švajger: Effective dendritic cell development is hampered by DC-SIGN ligation
18.20 – 18.35	Zala Jevnikar: Fine-tuning of integrin receptor LFA-1 by cathepsin X
19.00 – 20.30	Dinner
20.30 – 22.00	Poster session I
22.00	Social event

Friday, March 26, 2010

9.30 – 11.00	EATRIS Presentation: Rebecca Ludwig: Improving translational research in Europe through the infrastructure initiative EATRIS Irena Mlinarič Raščan: The European roadmap for research infrastructure in biomedical sciences
11.00 – 12.00	Kemomed Presentation: Gary Prescott: The recent developments of Biotek modular microplate readers for biochemical and cell based assays BioTek Instruments, Inc
12.00 – 13.00	Olympus, Presentation: Matjaž Mencej: The microscope FV10i
13.00 – 15.00	Lunch
15.00 – 16.30	Section 4: Tumour markers Chairs: Manfred Schmitt &Hans J. Nielsen
15.00 - 15.25	Manfred Schmitt: Current status of breast cancer biomarkers
15.25 - 15.50	Hans J. Nielsen: Biomarker directed chemotherapy to patients with stage II or III colon cancer
15. 50 -16.15	Damjana Kastelic: Investigation of biomarkers for gastric cancer using protein microarrays and heavy chain antibodies
16.15 – 16. 30	Nina Erčulj: MTHFR and TS polymorphisms influence the outcome of childhood acute lymphoblastic leukemia
16.30 – 17.00	Break
17.30 – 18.45	Section 5: Delivery systems in cancer - I Chairs: Elena Reddi & Stephen G. Bown
17.00 -1 7.25	Stephen G. Bown: The clinical role of photodynamic therapy (PDT)
7.25 - 17.50	Elena Reddi: Pegylated ORMOSIL nanoparticles for improved delivery of photosensitisers used in photodynamic therapy
17. 50 -18.15	Emanuele Papini: Haemocompatibility of super-stealth highly-PEGylated silica nano-carriers
18.15-18.30	Bojan Doljak: Multilevel targeting of tumour-associated proteolytic activity
18.30 – 18.45	Olga Vasiljeva: Development of multifunctional magnetoliposomes for imaging and cancer treatment
18.45 – 19.10	Declan Soden: Minimally invasive control of primary tumour endoscopic electroporation
19:10 - 20.30	Dinner
20.30 – 22.00	Poster session II
22.00	Social event

Saturday, March 27, 2010

8.30 – 10.45	Section 6: Stem cells in cancer Chairs: Tamara Lah & Rolf Bjerkvig
8.30 – 8.55	Rolf Bjerkvig: Cancer stem cells: Current controversies
8.55 – 9.10	Christian Schichor: Hypoxic tumour micromilieu induces recruitment and reprogramming of bone marrow derived progenitor cells in malignant gliomas
9.10 - 9.25	Henning Ulrich: Modulation of neurogenesis and gliogenesis of neural stem cells by bradykinin
9.25 – 9.40	Frits Thorsen: Novel brain metastases models development in immuno-deficient animals closely mimics the progression of metastatic brain tumours in patients
9.40 - 10.05	Jurgen Dittmer: Human mesenchymal stem cells induce E-cadherin degradation in breast carcinoma spheroids by activating ADAM 10
10.05 – 10.30	Miria Richetti: DNA double strand break repair in senescent cells and in adult stem cells
10:30. – 10.45	Uroš Rajčevič: Enrichment of tumorigenic stem-like cells in biopsy spheroids from colorectal cancer
10.40 – 11.15	Break
11.15 – 12.50	Section 5 – Delivery systems in cancer - II Chairs: Gregor Serša & Richard Heller
11.15 – 11.40	Justin Teissie: Targeted delivery by large unilamellar vesicles electrofusion with cells
11.40 – 12.05	Maja Čemažar: Electrotransfer of plasmid DNA into tissues for cancer gene therapy
12.05 – 12.20	Eldar Gadžijev: Electrochemotherapy for colorectal liver metastasis
12.20 – 12.35	Mojca Pavlin: The role of electrophoresis in gene electrotransfer
12.35 – 12.50	Vesna Todorovič: The effect of electrochemotherapy with cisplatin on metastatic potential of melanoma cells
13.00 – 15. 00	Lunch
15.00 – 16.55	Section 7 – New drugs and therapeutic targets Chairs: Simon Scott & Janko Kos
15.00 – 15.25	Simon Scott : Utilising radiation for activation of gene therapy in hypoxic tumours
15. 25 - 15. 40	Urška Kamenšek: Anti-tumour effect of radio-gene therapy with an inducible plasmid containing the therapeutic gene interleukin-12 under the control of the inducible p21 promoter
15.40 – 15.55	Jerica Sabotič: Mushrooms as a source of proteins with immunomodulatory and antitumour properties
15.55 – 16.10	Aleš Berlec: Engineered lactic acid bacteria capable of binding Tumor necrosis factor α
16.10 - 16.25	Matjaž Jeras: Systems biology is providing new tools for diagnostics and therapy follow up in clinical trials
16.25 – 16.40	Tatyana A. Korolenko: Tissue inhibitor of matrix metalloproteases type 1 and MMP activity in murine tumor development and metastazing
16.40 – 16.55	Bojana Mirković: Nitroxoline: A reversible, potent and selective inhibitor of cathepsin B
16.55 – 17.30	Break
17.30 – 18.30	Closing lecture: Chair: Janko Kos Matthew Bogyo: Small molecule probes of protease function: applications to molecular imaging
18.30 – 19.00	Concluding remarks, Closing of the meeting
20.00 – 24.00	Conference dinner (Restaurant Fabula)

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Program

Conference Programme

Wednesday, March 24, 2010

Thursday, March 25, 2010

Friday, March 26, 2010

Saturday, March 27, 2010

Sunday, March 28, 2010: Departure